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Scientist III, Upstream

35 / per week - Full-Time
Cowley ,

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

We are currently recruiting for a Scientist III, Upstream to join the team.  The purpose of this role is to perform and report laboratory-based experiments or investigations in accordance with scientific or regulatory requirements in line with departmental objectives

Your responsibilities in this role would be:

  • Develop and optimize upstream processes for producing lentiviral vectors, working within the Process R&D group.
  • Design and execute small scale and laboratory scale bioreactor cell culture activities for scale-up/scale-down of existing bioprocesses. Support new product process development and scale-up activities. This requires working with miniature cell-cultivation systems and the scale-up to larger bioreactors.
  • Involvement in activities ranging from vector manufacture, process optimization, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
  • Perform routine cell culture activities.
  • Lead the design and execution of experiments /investigations in accordance with correct methodologies and procedures under the direction of the Team Leader or a senior scientist
  • Carry out such other tasks as are required from time to time for the efficient running of the Company’s business upon request from your line manager or a Director of the Company.
  • Analyse and interpret experimental data for reporting to stakeholders within OXB
  • Prepare written reports to a high standard and present data within the Process R&D group.
  • Liaise with other members of the Process R&D group and assist with other development activities where appropriate.
  • Liaise with diverse internal and external collaborators in order to streamline process activities, data interpretation and introduction of new technologies.
  • An understanding of, or experience in downstream processing would be beneficial.
  • Accountable for own performance in alignment with group objectives and deadlines.
  • Ensure a high standard of record keeping and documentation of experiments and investigations.
  • Contribute to the efficient and safe operation of the laboratory
  • Writing of departmental risk assessments, SOPs and other documentation where appropriate.

To be successful in this role, you will have the following skills and experience:

  • Minimum BSc Degree programme level, a postgraduate degree and/or relevant experience
  • An understanding of and experience in process development and/or gene therapy would be an advantage
  • A sound understanding of basic cell culture principles and processes
  • An understanding of metabolite analysis in the context of mammalian cell culture and media development
  • Fluency in written and spoken English
  • Pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere
  • Experience with suspension cell culture
  • Experience with the operation of laboratory, pilot or production scale cell culture bioreactors is desired
  • Practical understanding of how own area of operation relates to the overall business of OXB.
  • Understanding of laboratory health and safety requirements.
  • Competency in data capture, reporting and management systems.
  • Capable of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives.
  • Knowledge of the overall research programme in your group.
  • Awareness of regulatory requirements e.g. GMP, GLP, GCP and/or Validation and Quality Management systems.
  • Familiar with data analysis software packages such as but not limited to Microsoft Excel, JMP, Design Expert™, Graphpad Prism

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives.

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