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Scientist, Upstream

35 / per week - Full-Time
Cowley ,

Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.

Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market.

Due to our continued growth we are looking for a Scientist, Upstream within Process R&D. 

Key Responsibilities and Accountabilities:

  • Develop and optimize upstream processes for producing lentiviral vectors, working within the Process R&D group.
  • Execute small scale and laboratory scale bioreactor cell culture activities for scale-up/scale-down of existing bioprocesses. Support new product process development and scale-up activities.  This requires working with miniature cell-cultivation systems and the scale-up to larger bioreactors.
  • Involvement in activities ranging from vector manufacture, process optimization, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
  • Performing high-throughput upstream studies and applying DoE methods to cell culture activities.
  • Liaise with other members of the Process R&D group and assist with other development activities where appropriate.
  • Routinely interact with the in-house manufacturing team and facilitate technology transfer of processes to the manufacturing facility and/or external CMOs as necessary.
  • Perform routine cell culture activities.
  • Carry out such other tasks as are required from time to time for the efficient running of the Company’s business upon request from your line manager or a Director of the Company.
  • Experience with downstream processing is not essential but would be beneficial.

Key skills and requirements:

  • a graduate or postgraduate degree (or equivalent qualification) in a relevant scientific discipline
  • a sound understanding of basic cell culture principles and processes
  • fluency in written and spoken English

 In addition, desirable skills include:

  • pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere
  • experience with adherent and/or suspension cell culture
  • experience with the operation of laboratory, pilot or production scale cell culture bioreactors

Person Specification

Candidates will be recognized experts in upstream processing including cell culture process design and bioreactor operation. They will be primarily involved in the production and characterisation of a variety of therapeutic candidates in support of projects from early stage research to pre-clinical programs.  

PR&D works with our research teams involved in vector and cell engineering to ensure the seamless transfer of processes from research to manufacturing. The scope of work may include, but is not limited to vector production, small scale cell culturing, bioreactor process development and verification, data analysis and project reporting. The individual must have a demonstrated ability to work independently and to manage multiple projects either through direct supervision or in collaboration with a project team. The individual must be innovative and creative, show initiative, collaborative ability and have good general science management skills. Applicants are expected to have good time management skills, with the ability to adapt to rapid changes in projects priorities and meet aggressive timelines. These individuals should also enjoy working in a team setting and be able to work well with research scientists.

About Process Research & Development

The Process R&D group has a core function within Manufacturing Development.  It consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for systematic evaluation, optimisation and understanding for delivery to Manufacturing. As the focus shifts towards delivering processes and materials to support our LentiVector® platform products through later-stage development and market supply, PR&D is well positioned to ensure our products are manufactured using processes that are scalable, robust and reproducible as well as commercially viable and regulatory compliant.

No agencies please


Benefits Summary

  • Competitive pension scheme     
  • Generous holiday entitlement
  • Private Health Care
  • Health Cashback Plan
  • Employee Assistance Plan (EAP)              
  • Life Assurance
  • Childcare Vouchers
  • Discount Portal
  • Discretionary Share Option Scheme
  • Discretionary Sharesave Scheme
  • Cycle To Work Scheme
  • Public Transport Season Ticket Loans

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