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Principal Scientist, CEG

35 - 0 / per week - Full-Time
Cowley ,

Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.

Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market.

Our recent successes are driving significant growth. As such, we are looking for a Principal Scientist to join our Cell Engineering Group. The Cell Engineering Group (CEG) is part of the Platform Research Department. CEG is involved in the development of stable lentiviral vector packaging and producer cell lines. The CEG is recruiting a highly motivated Principal Scientist to lead a small group with the development and generation of new cell lines.

A highly motivated individual is sought to work within this team orientated group. The successful candidate will be involved in:

  • Leading and managing a small team
  • The development of stable lentiviral vector producer cell lines and the screening of resulting producer clones
  • An automated platform for the high throughput selection and screening of cell lines
  • The development and optimisation of lentiviral vector production
  • The characterisation of lentiviral vector for advancement to preclinical studies
  • Other activities within the Research Department

Key Tasks

  • Management of team members
  • Cell line engineering for the development of new cell lines for the production of lentiviral vector products
  • Extensive cell culture
  • Molecular biology techniques
  • LV analytics
  • Organisation of parallel projects/activities
  • Support other members of both the CEG team and wider Platform Research Department as required

Required Skills/Knowledge/Qualifications

  • Post-doctoral/Industry experience in a relevant Biological Science subject
  • Line management experience is essential
  • Relevant lab technical experience with particular emphasis on Molecular Biology, Tissue Culture and PCR-based techniques
  • Line management experience would be an advantage
  • Demonstrable excellent lab-based skills
  • Demonstrable ability to work well in a team
  • Ability to demonstrate strong written and oral communication skills


  • Experience with automation in the laboratory
  • Experience with communicating and interaction with third party clients/collaborators/partners
  • Experience working in a commercial/industry setting is preferred
  • Experience with cell culture automation systems would be an advantage
  • Good intuition & problem solving skills

No agencies please

Benefits Summary

  • Competitive pension scheme     
  • Generous holiday entitlement
  • Private Health Care
  • Health Cashback Plan
  • Employee Assistance Plan (EAP)              
  • Life Assurance
  • Childcare Vouchers
  • Discount Portal
  • Discretionary Share Option Scheme
  • Discretionary Sharesave Scheme
  • Cycle To Work Scheme
  • Public Transport Season Ticket Loans

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