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Principal Scientist, Analytical Development Group

35 - 0 / per week - Full-Time
Cowley ,

Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.

Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market

Oxford BioMedica’s Analytical Development Group (ADG) is seeking to strengthen its team by recruiting an experienced scientist who can contribute to providing first rate analytical development for external partnerships and for the company’s portfolio of cell and gene therapies. The group functions in a multi-disciplined innovative environment whilst also adhering to internal and external quality systems. ADG is part of the Research Department but works closely with manufacturing, clinical and analytical services at all stages of development. The team is responsible for assay development and subsequent validation to support the GMP manufacturing process and early phase development.

A highly motivated Principal Scientist is sought to support and provide expertise in the Analytical Development Group. The successful candidate will be expected to:

Key responsibilities and accountabilities:

  • Have responsibility for the research, development and implementation of new and existing assays to support internal and external cell and gene therapies programmes
  • Support the development of Oxford BioMedica’s pipeline and work closely with Project Management
  • Line management of junior scientists
  • Troubleshoot assay performance issues as and when required
  • Drafting and preparation of standard operating procedures for new assays
  • Assist in the scheduling, management and execution of the ADG to deliver programs of work
  • Act as project manager for validation, qualification and transfer studies both internally and with external partnerships.
  • Training members of the Analytical Services Group (ASG) to perform newly developed and validated assays

Key skills and requirements: 

  • Previous experience with assay development and validation in an industrial setting
  • Experience with qPCR and protein analysis
  • An understanding of lentiviral vectors and gene therapy
  • Experience of line management
  • Use of statistics as applied to assay validation
  • The ability to train others in the conduct of analytical techniques

 Person Specification:

  • BSc Degree in Life Sciences/Science/Analytical Science
  • Demonstrated ability to work independently as well as in a team
  • Good written and verbal communication skills
  • Ability to undertake projects to agreed timelines and adapt to rapid changes in project priorities

*no agencies please*

Benefits Summary

  • Competitive pension scheme     
  • Generous holiday entitlement
  • Private Health Care
  • Health Cashback Plan
  • Employee Assistance Plan (EAP)              
  • Life Assurance
  • Childcare Vouchers
  • Discount Portal
  • Discretionary Share Option Scheme
  • Discretionary Sharesave Scheme
  • Cycle To Work Scheme
  • Public Transport Season Ticket Loans

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