Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.
Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market
Oxford BioMedica’s Analytical Development Group (ADG) is seeking to strengthen its team by recruiting an experienced scientist who can contribute to providing first rate analytical development for external partnerships and for the company’s portfolio of cell and gene therapies. The group functions in a multi-disciplined innovative environment whilst also adhering to internal and external quality systems. ADG is part of the Research Department but works closely with manufacturing, clinical and analytical services at all stages of development. The team is responsible for assay development and subsequent validation to support the GMP manufacturing process and early phase development.
A highly motivated Principal Scientist is sought to support and provide expertise in the Analytical Development Group. The successful candidate will be expected to:
Key responsibilities and accountabilities:
Have responsibility for the research, development and implementation of new and existing assays to support internal and external cell and gene therapies programmes
Support the development of Oxford BioMedica’s pipeline and work closely with Project Management
Line management of junior scientists
Troubleshoot assay performance issues as and when required
Drafting and preparation of standard operating procedures for new assays
Assist in the scheduling, management and execution of the ADG to deliver programs of work
Act as project manager for validation, qualification and transfer studies both internally and with external partnerships.
Training members of the Analytical Services Group (ASG) to perform newly developed and validated assays
Key skills and requirements:
Previous experience with assay development and validation in an industrial setting
Experience with qPCR and protein analysis
An understanding of lentiviral vectors and gene therapy
Experience of line management
Use of statistics as applied to assay validation
The ability to train others in the conduct of analytical techniques
BSc Degree in Life Sciences/Science/Analytical Science
Demonstrated ability to work independently as well as in a team
Good written and verbal communication skills
Ability to undertake projects to agreed timelines and adapt to rapid changes in project priorities